Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-813-5
CAS number: 5989-27-5
Table 1: Individual and mean scores of
conjunctivae, iris and cornea
Time after treatment
Mean (24, 48 and 72 hours)
In an eye irritation study conducted
according to the OECD Guideline 405 and in compliance with GLP, three
male rabbits of the New Zealand White strain were exposed to 0.1 mL of
undiluted d-limonene in one of the eyes while the other eye corresponded
to the control. The eyes were examined for irritation scores at 1 hour
and 1, 2, 3, 4 and 7 days after dosing.
Instillation of d-limonene resulted in
slight to moderate redness of conjunctivae associated with moderate
chemosis in all treated animals after 1 hour of instillation. The
irritation completely resolved within 7 days. Mean individual scores at
24, 48 and 72 hours after exposure for the 3 animals were 0, 0, 0 for
cornea score; 0, 0, 0 for iris score; 0.3, 1, 1.3 for conjunctivae score
and 1, 0.3, 1 for chemosis score.
Therefore, d-limonene is not classified as
irritating to the eyes according to Directive 67/548/EEC and CLP
Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again