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EC number: 292-607-4
CAS number: 90640-86-1
Distillate from the fractional distillation of coal tar of bituminous coal, with boiling range of 240°C to 400°C (464°F to 752°F). Composed primarily of tri- and polynuclear hydrocarbons and heterocyclic compounds.
The positive effects noted without S9 were weak and not
reproducible in either experiment (see below).
In the presence of S9 clear dose-related increases in the
mutation rates were found in TA 98 and 1537 and a weak positive
correlation in TA 100 and TA 102, reproducible at non-cytotoxic
concentrations in both experiments. The most responsive tester strain
was TA 98.
[Mutation factors (+S9) = 3 - 14x above background with maximum in TA 98]
In either experiment, no biological relevant increases in the mutation
rate were seen in TA 1535.
No relevant increases in TA 98, TA 100, TA 1537, and TA 102 (-S9);
relevant increases in TA 98, TA
100, and TA 1537 (>= 10 µg/plate, +S9)
Relevant increases in TA 98 (>= 15 µg/plate, -S9);
relevant increases in TA 98,
TA 100, TA 1537, and TA 102 (>= 5 - 500 µg/plate, +S9)
Dose-response relationship of the reversion rate was observed with each
Data for assessing the mutagenicity of the
substance distillates (coal tar) heavy oils (anthracene
oil high (> 50 ppm) BaP, AOH) is
only available from one mutagenicity test. Additional tests have not
been performed as AOH is classified as Carc. 1B (Regulation (EC) No.
1272/2008) and as Muta. 1B due to its benzo[a]pyrene (BaP) content of up
to 1.5 % (see below).
For AOH, a bacterial reverse mutation assay
(Ames test) was performed. In this test, five different strains of S.
typhimurium were tested with and without metabolic activation. No
mutagenic response was observed without metabolic activation. Positive
results were obtained with metabolic activation for four of the five
bacterial strains tested. One strain (TA 1535) did not show any
biologically relevant increase in the mutation rate neither with nor
without metabolic activation.
Based on this experimental result and due to
the BaP content of AOH, the substance is identified as mutagen.
The substance distillates (coal tar) heavy
oils (anthracene oil high (> 50 ppm)
BaP, AOH) is self-classified as mutagenic Cat. 1B due to its content of
benzo[a]pyrene (up to 1.5 %). Benzo[a]pyrene is classified as mutagenic
Cat. 1B (Regulation (EC) No 1272/2008, Annex VI, Table 3.1), and the
generic concentration limit of a mutagen Cat. 1B in a mixture triggering
classification of the mixture itself as mutagenic Cat. 1B is ≥ 0.1 %
(Regulation (EC) No 1272/2008, Table 3.5.2).
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