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EC number: 292-607-4
CAS number: 90640-86-1
Distillate from the fractional distillation of coal tar of bituminous coal, with boiling range of 240°C to 400°C (464°F to 752°F). Composed primarily of tri- and polynuclear hydrocarbons and heterocyclic compounds.
Guinea pig maximisation test with the test substance Creosote SNCF:
Result of skin sensitisation test (Challenge)
Number of animals with signs of allergic reactions /number of animals in group
Positive control (not concurrent)
scored after 24 h
0/10average score 0.0
17/19average score 1.2
5/5average score 2.6
scored after 48 h
6/19average score 0.4
5/5average score 2.3
*Scoring system: Draize
0 = no reaction; 1 = slight
erythema; 2 = well visible erythema; 3 = moderate erythema; 4 = strong
A spontaneous death occurred in one
female animal on day 9 with no relation to the treatment.After
challenge with the test article, there was a brownish discolouration at
the site of application and, additionally, dryness of the skin after 48
Discolouration but no dryness is also
reported for the not-induced control group.
The induced animals showed slight to
well defined erythema (definition see table below):
h after challenge exposure: 5/19 score 2, 12/19 score 1 and 2/19 score 0 and
h after challenge exposure: 1/19 score 2, 5/19 score 1, and 13/19 score
No data on sensitisation is available for the
substance distillates (coal tar),
heavy oils (anthracene oil high (> 50 ppm) BaP, AOH) itself.
Data obtained originate from the closely related tar oil creosote and
from the minor constituent benzo[a]pyrene (BaP).
Due to the similar production process
(fractionated distillation of coal tar using overlapping conditions),
composition of both tar substances correspond to each other. Major
components are mid-range PAH for both substances (3- and 4-ring PAH)
with some additional 2-ring PAH in creosote but not in AOH.
3- and 4-ring PAH are considered to
contribute predominantly to the sensitising potency of creosote. 2-ring
PAH will not have an additional substantial effect. But in case they
have, using creosote data to represent the sensitising potency of AOH
will result in overestimation of the sensitising effect of AOH as worst
case. Thus, use of creosote as supporting substance for characterisation
of the sensitising potential of AOH is justified.
Creosote was found to be skin sensitising in
a guinea pig maximisation test (Clouzeau J, 1993d). Based on this
result, AOH is characterised as sensitising. Furthermore, BaP as
constituent of AOH showed itself a strong sensitising effect in a
delayed hypersensitivity/contact sensitisation test (Old et al.1963)
after intradermal induction in the foot pad of guinea pigs. Based on
both results, AOH is identified as skin sensitiser.
For respiratory sensitisation, no
experimental data has been located. Due to the low vapour pressure of
AOH at ambient temperature (0.6 Pa, see Chapter 1.3), respiratory
effects are not expected. From occupational experience, there has been
no evidence of respiratory sensitisation in exposed workers.
Skin sensitising potential was demonstrated
for distillates (coal tar), heavy oils (AOH) in a studies with the
supporting substance creosote and in a study with the AOH constituent
BaP is classified as skin sensitising Cat. 1
according to Annex VI, Table 3.1 of Regulation (EC) No 1272/2008.
According to table 3.5.2 of this regulation, the generic concentration
limit of a constituent classified as Skin Sens. 1ina
mixture that triggers classification of the mixture the same way as the
constituent is≥ 1.0 %.Due
to this provision, AOH is to be classified (self-classification) as skin
sensitising Cat. 1.
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