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EC number: 206-996-5
CAS number: 420-46-2
Rate of metabolism was determined from the decline curves of HFC-143a in
the exposure chambers. Vmax = 4.15 +/- 0.1 mg/hr-kg and Km = 4.37 +/-
HFC-143a is poorly adsorbed into the blood from air, as shown by the low
blood air partition coefficient. The compound is also poorly soluble in
tissues. The PBPK model indicates that nearly all is cleared from the
blood within 2 hours after the end of a 6 hour exposure. It is
metabolized primarily to trifluoroethanol at a low rate and excreted
either unchanged or as the glucuronide conjugate. The low uptake and
rapid clearance demonstrate that it will not bioaccumulate.
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