Registration Dossier
Registration Dossier
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EC number: 206-996-5 | CAS number: 420-46-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study from reliable laboratory, report available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1993
Materials and methods
- Principles of method if other than guideline:
- hepatocytes from male Sprague Dawley rat liver were isolated and exposed to atmospheres of HFC-143a for 4 days. At the end of the exposure, palmitoyl-CoA-oxidase activity was measured.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1-trifluoroethane
- EC Number:
- 206-996-5
- EC Name:
- 1,1,1-trifluoroethane
- Cas Number:
- 420-46-2
- Molecular formula:
- C2H3F3
- IUPAC Name:
- 1,1,1-trifluoroethane
- Details on test material:
- Test material identified as Forane 143A in report
Constituent 1
Results and discussion
Any other information on results incl. tables
No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days.
Applicant's summary and conclusion
- Conclusions:
- No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells.
- Executive summary:
It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells when tested by measuring palmitoyl-CoA-oxidase activity.
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