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EC number: 206-996-5
CAS number: 420-46-2
Rats were dosed five days per week for one year by gavage at a dose level of 300 mg/kg body weight. HFC-143a was dissolved in corn oil. They were held for an additional year and sacrificed. No treatment related tumors were found.
HFC-143a did not show a carcinogenic response.
Test article (HFC-143a) did not cause a carcinogenic response in this
screening study. (Ref. Longstaff, E., Robinson, M., Bradbrook, C.,
Styles, JA., and Purchase, IFH., (1984). Genotoxicity and
Carcinogenicity of fluorocarbons: Assessment by short-term in vitro
tests and chronic exposures in rats. Toxicol. Appl. Pharmacol. 72, 15
Carcinogenicity: via oral route (target organ): other: all gross lesions and masses
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