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EC number: 200-889-7
CAS number: 75-65-0
two-generation reproductive toxicity study, MTBE was administered to 25
Sprague-Dawley rats/sex/group by whole body inhalation at target
concentrations of 0, 400, 3000 and 8000 ppm for 10 weeks prior to mating. Males
continued exposure until delivery of the F1-litters. Females
continued exposure during mating, gestation and lactation until weaning
of the offspring. There
were no adverse effects on any reproductive parameters including
pregnancy rates, gestation days, and mating and fertility indices. Toxic
effects including clinical signs of CNS depression, and reduced body
weight and/or body weight gain were observed in the F0 and F1 parental
generations at 3000 and 8000 ppm. Signs
of developmental toxicity such as lowered body weight and body weight
gains were observed in the F1 and F2 litters when parents were exposed
to 3000 or 8000 ppm but adverse effects occurred only in the presence of
maternal toxicity. MTBE
and by analogy its metabolite tertiary butyl alcohol are not considered
to be reproductive or developmental toxicants.
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