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EC number: 200-889-7
CAS number: 75-65-0
significant differences occurred in the reproductive endpoints of
(weight of testis, epididymis, and cauda; sperm motility, count, and
morphology) or females (estrous cycle length or percentage of time spent
in the various estrous stages) exposed to 542, 1080 or 2101 ppm tertiary
subchronic toxicity study, tertiary butyl alcohol was administered to 10
B6C3F1 mice/sex/group by inhalation exposure at 0, 134, 272, 542, 1080
and 2101 ppm for 6 hr/day, 5 days/wk for 13 weeks. Based on a single
compound-related death and a marked increase in segmented neutrophil
count, the NOAEL in male mice is considered to be 1080 ppm.
than a decrease in final body weight and increase in relative liver
weights, no effects were observed in female mice. In the absence of
mortality, clinical signs, hematological effects or gross/microscopic
effects, the NOAEL in female mice is considered to be 2101 ppm.
Nephropathy observed in similarly exposed male rats was not observed in
either sex of mice. Tertiary butyl alcohol had no adverse effects on
reproductive endpoints in either sex.
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