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EC number: 200-889-7
CAS number: 75-65-0
In an acute
inhalation study, a single group of 5 male and 5 female rats was exposed
whole-body for 4 hours to a vapor concentration of 10000 ppmV tertiary
butyl alcohol and observed for 14 days. One female was found dead on
study Day 3. The principal signs observed during exposure were
indicative of central nervous system depression and included dyspnea and
prostration in all animals. These same signs, along with generalized
weakness, appeared in several animals of each sex during the
post-exposure period but were fully reversible by study
termination. Gross pathological effects observed at necropsy were
limited to focal areas of redness on the lungs. Tertiary butyl alcohol
is classified as Category 4 for acute lethality by the inhalation
route. Tertiary butyl alcohol is classified as Category 3 for Specific
Target Organ Toxicity – Single Exposure.
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