Registration Dossier
Registration Dossier
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EC number: 700-111-0 | CAS number: 148528-05-6
Endpoint summary
Administrative data
Description of key information
Additional information
Freshwater aquatic toxicity data are available for three trophic levels: fish, invertebrates and algae. An acute fish toxicity study was conducted to determine the dose levels for an 8 week bioconcentration study. Mortalities were observed over a 48 hour period. The results obtained determined the 48 hour LC50, which was found to be 73.6 mg/L under the test conditions. The 48-hour EC50 of MODA for the immobilisation of Daphnia magna in non-adjusted media was 37.5 mg/L (95% confidence limits of 34.0 and 48.6 mg/L) and in pH-adjusted media it was 62.8 mg/L (95% confidence limits of 49.1 and 84.1 mg/L). The NOEC of MODA with Daphnia magna was 21.1 and 21.0 mg/L respectively, in non-adjusted and pH-adjusted media. Long term exposure was not tested based on strictly controlled conditions and no significant exposure as laid down in Annex XI section 3.2 (a). A detailed justification is attached to this dossier.
After 72 hours of exposure to MODA in an alga growth inhibition test, in non-adjusted media the EbC50 and ErC50, were 22.0 and 34.4 mg/L respectively. In pH-adjusted media, the EbC50 and ErC50, were 69.3 and >100 mg/L respectively. The NOEC for the area under the growth curve and for growth rate in non-adjusted media were 0.82 and 1.84 mg/L respectively and in pH-adjusted media both were 22.0 mg/L.
The toxicity test to microorganisms is not required if there is no emission of the substance to a sewage treatment plant. Testing is waived on the basis that there is no emission of MODA to a sewage treatment plant.
These results obtained from the acute toxicity tests with daphnia and algae suggest that the pH of the test media, increased by the presence of the test substance, was partially responsible for the toxicity observed in the non-adjusted media.
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