Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 700-111-0 | CAS number: 148528-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
- Conclusions:
- It is considered that performing irritancy studies via the dermal or ocular routes are unlikely to yield any additional data to those already available. It is considered the risk phrase R35 'Causes severe burns' should be assigned to MODA.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Conclusions:
- It is considered that performing irritancy studies via the dermal or ocular routes are unlikely to yield any additional data to those already available. It is considered the risk phrase R35 'Causes severe burns' should be assigned to MODA.
Reference
Based on the physical characteristics of this test substance it is likely that it will be absorbed dermally, and will produce high pH values when in contact with moisture either from the skin or the ocular environment. The oral gavage studies indicate that aqueous preparations of the test substance resulted in trauma (gastrointestinal haemorrhage, erosion and ulceration) and adaptive changes (mucosal hyperplasia in the fore-stomach associated with oedema and cellular infiltration) which are considered to be due to the administration of a strongly alkaline preparation.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Based on the physical characteristics of this test substance it is likely that it will be absorbed dermally, and will produce high pH values when in contact with moisture either from the skin or the ocular environment. The oral gavage studies indicate that aqueous preparations of the test substance resulted in trauma (gastrointestinal haemorrhage, erosion and ulceration) and adaptive changes (mucosal hyperplasia in the fore-stomach associated with oedema and cellular infiltration) which are considered to be due to the administration of a strongly alkaline preparation.
Justification for selection of skin irritation / corrosion endpoint:
strongly caustic
Justification for selection of eye irritation endpoint:
strongly caustic
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
It is considered that performing irritancy studies via the dermal or ocular routes are unlikely to yield any additional data to those already available. MODA has been assigned Skin Corr 1A with hazard statement H314 'Causes severe skin burns and eye damage'.
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