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EC number: 700-111-0
CAS number: 148528-05-6
A study was performed at Gotenba Research Center, Bozo Research Center
Inc., Japan, on behalf of Kuraray Co., Ltd., to investigate the changes
caused by 2-methyl-1,8-octanediamine (MODA) and their reversibility in
Sprague-Dawley rats when administered daily by oral gavage over a 28 day
period followed by a two week recovery period. The study was conducted
according to the relevant Japanese Guidelines and in accordance with the
principles of GLP. The number of animals per group was 12 males and 12
females each in the control and 150 mg/kg groups and 6 males and 6
females in the 6 and 30 mg/kg groups. Six males and 6 females each from
the control and 150 mg/kg groups were used in the 2-week recovery study
after treatment for 28 days. One male and two females died after
administration of 150 mg/kg of MODA, and both males and females from
this group showed changes mainly attributable to the irritating effects
of the test substance. Animals from this group also showed increases in
GPT activity (males) and increases in activated partial thromboplastin
time (females). However, no effects of the test substance were observed
in the 6 or 30 mg/kg group. Based on these findings, the
no-observed-effect level (NOEL) for MODA was estimated to be 30
mg/kg/day under the conditions of the present study.
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