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EC number: 640-387-9
CAS number: 61477-40-5
The substance (R)-3-Aminobutan-1-ol was tested for its mutagenic
potential based on the ability to induce point mutations in selected
loci of several bacterial strains, i.e. Salmonella typhimurium and
Escherichia coli, in a reverse mutation assay. An increase in the number
of his+ or trp+ revertants was not observed in the standard plate test
or in the preincubation test either without S9 mix or after the addition
of a metabolizing system. According to the results of the study, the
test substance (R)-3-Aminobutan-1-ol is not mutagenic in the Salmonella
typhimurium/Escherichia coli reverse mutation assay under the
experimental conditions chosen.
According to the results of the study, the test substance did not lead
to an increase in the number of revertant colonies either without S9 mix
or after adding a metabolizing system in several experiments carried out
independently of each other (standard plate test and preincubation
assay). In the 2nd Experiment using the tester strain E.coli WP2 uvrA no
bacterial growth occured. It has to be considered that the lacking
bacterial growth was caused by a technical error. Therefore, this
experimental part was repeated in the 3rd Experiment. Besides, the
results of the negative as well as the positive controls performed in
parallel corroborated the validity of this study, since the values
fulfilled the acceptance criteria of this study. In this study with and
without S9 mix, the number of revertant colonies in the negative
controls was within the range of the historical negative control data
for each tester strain. In addition, the positive control substances
both with and without S9 mix induced a significant increase in the
number of revertant colonies within the range of the historical positive
control data or above. [BASF, 2008]
No need for
classification according to Annex VI of Directive 67/548/EEC and
according to the EU Classification, Labelling and Packaging of
Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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