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EC number: 640-387-9
CAS number: 61477-40-5
LD50(oral,rat): > 300 <2000 mg/kg bw
Dose (mg/kg bw):
No. of animals:
Under the conditions of this study the median lethal dose of
3-Amino-butan-1-ol after oral administration was found to be greater
than 300 mg/kg bw and less than 2000 mg/kg bw in rats.
There are no studies available for (R)-3 -Amino-butan-ol, only for the
racemat 3-Amino-butan-1 -ol.
In an acute oral toxicity study performed according to the Acute Toxic
Class method (OECD 423), doses of 2000 and 300 mg/kg bw of the test item
3-Amino-butan-1-ol (undiluted or preparations in deionized water) were
administered by gavage to three test groups of three fasted Wistar rats
each (2000 mg/kg bw in 3 females, 300 mg/kg bw in 6 females). All
animals of the 2000 mg/kg bw test group died at hour 5 or on study day 1
or 2. No mortality occurred in both 300 mg/kg bw test groups. Clinical
findings in the 300 mg/kg bw test group were impaired general state,
dyspnoea, piloerection, reduced defecation, gasping. There were no
macroscopic pathological findings in the surviving animals of both 300
mg/kg test groups sacrificed at the end of the observation period. The
acute oral LD50 was calculated to be LD50, oral, rat > 300 < 2000 mg/kg
bw. [BASF, 2014]
EU classification according to Annex I of Directive 67/548/EEC: Xn, R22
According to the EU Classification, Labelling and Packaging of
Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 subtance is
classified as Cat. 4 harmful if swallowed
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