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EC number: 603-333-5 | CAS number: 129423-55-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Start date: 03/02/2021
End Date: 17/03/2021 - Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Remarks:
- Special effusion cell, made of glass, 2 mL, with a crimp cap at its top. It was closed by an Al crimp cap with a big hole, a slide of aluminium with a small aperture in the cap and sealed with PTFE rings.
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0 Pa
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Conclusions:
- The vapour pressure of the test item was determined at nine different temperatures (30 - 150 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 1 - 6 (nominal temperature 30 - 105 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard devia-tions of less than 23 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid. - Executive summary:
The vapour pressure of the test item was determined at nine different temperatures (30 - 150 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 1 - 6 (nominal temperature 30 - 105 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard devia-tions of less than 23 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid.The following vapour pressures at 20°C and at 25°C were calculated:
- Vapour pressure at 20°C : 6.18*10-05 Pa
- Vapour pressure at 25°C : 8.51*10-05 Pa
Reference
The vapour pressure of the test item was determined at nine different temperatures (30 - 150 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 1 - 6 (nominal temperature 30 - 105 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard devia-tions of less than 23 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid.
Description of key information
The vapour pressure of the test item was determined according to OECD 104 resp. EU A.4 using the effusion method (weight loss); with the following vapour pressures at 20°C and at 25°C calculated from the regression equation:
- Vapour pressure at 20°C : 6.18*10-05 Pa
- Vapour pressure at 25°C : 8.51*10-05 Pa
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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