Registration Dossier
Registration Dossier
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EC number: 237-860-3 | CAS number: 14024-63-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')zinc
- EC Number:
- 237-860-3
- EC Name:
- Bis(pentane-2,4-dionato-O,O')zinc
- Cas Number:
- 14024-63-6
- Molecular formula:
- C10H14O4Zn
- IUPAC Name:
- zinc bis(4-oxopent-2-en-2-olate)
- Test material form:
- solid: particulate/powder
Constituent 1
In vitro test system
- Test system:
- human skin model
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- The epidermis surface had previously been moistened with 5 μI of sterile distilled water to improve contact between the solid test item and the epidermis.
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- yes, concurrent MTT non-specific colour control
- Duration of treatment / exposure:
- 15 minutes
- Duration of post-treatment incubation (if applicable):
- 42 hours
- Number of replicates:
- Triplicate tissues were treated with the test item
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- mean value
- Value:
- 105.1
- Vehicle controls validity:
- not examined
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The relative mean viability of the test item treated tissues was 105.1 % after the 15-Minute exposure period.
The test item was considered to be Non-lrritant.
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