Registration Dossier
Registration Dossier
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EC number: 237-860-3 | CAS number: 14024-63-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')zinc
- EC Number:
- 237-860-3
- EC Name:
- Bis(pentane-2,4-dionato-O,O')zinc
- Cas Number:
- 14024-63-6
- Molecular formula:
- C10H14O4Zn
- IUPAC Name:
- zinc bis(4-oxopent-2-en-2-olate)
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Three test animals were purchased from Harlan Winkelmann GmbH, 33178 Borchen, Germany
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2 mL of sesame oil
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 females
- Control animals:
- no
- Details on study design:
- temperature: 19 - 24 °C
humidity: 30 - 70 %
light/dark: 12/12 h
acclimatization time: 5 days
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 of 3 animals died at day 1 after application. 2 animals survived the test period of 15 days.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After application of 2000 mg/kg bw of the test substance 1 of 3 animals died.
Thus the LD50 can be determined as > 2000 mg/kg bw.
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