Registration Dossier
Registration Dossier
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EC number: 278-917-2 | CAS number: 78479-03-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June to July 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- Adopetd 1981-05-12
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- [1α,3β(Z)]-(±)-3-[2-chloro-2-(4-chlorophenyl)vinyl]-2,2-dimethylcyclopropanecarboxylic acid
- EC Number:
- 278-917-2
- EC Name:
- [1α,3β(Z)]-(±)-3-[2-chloro-2-(4-chlorophenyl)vinyl]-2,2-dimethylcyclopropanecarboxylic acid
- Cas Number:
- 78479-03-5
- Molecular formula:
- C14 H14 Cl2 O2
- IUPAC Name:
- (1R,3S)-3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropane-1-carboxylic acid
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WINKELMANN, Borchen, Kreis Paderborn (Germany)
- Weight at study initiation: ca. 160-200 g
- Housing: Makrolon cages Type III (5 animals per cage), Low-dust wood pellets were used as litter.
- Diet: "Altromin 1324 - dietary diet for rats and mice" (producer: Altromin GmbH)
- Water (e.g. ad libitum): tap water.
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2°C
- Humidity (%): 40 - 60 %
- Photoperiod (hrs dark / hrs light): 12 hours / 12 hours
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- <= 5 µm
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 20 L
- Method of holding animals in test chamber: tubes
- Treatment of exhaust air: filtration
- Temperature: etwa 23°C
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 340 - 380 - 445 mg/m3 of air
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 388 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No
- Clinical signs:
- other: None
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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