[1α,3β(Z)]-(±)-3-[2-chloro-2-(4-chlorophenyl)vinyl]-2,2-dimethylcyclopropanecarboxylic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June to July 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

Adopted 1981-05-12

Deviations:

not specified

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

[1α,3β(Z)]-(±)-3-[2-chloro-2-(4-chlorophenyl)vinyl]-2,2-dimethylcyclopropanecarboxylic acid

EC Number:

278-917-2

EC Name:

[1α,3β(Z)]-(±)-3-[2-chloro-2-(4-chlorophenyl)vinyl]-2,2-dimethylcyclopropanecarboxylic acid

Cas Number:

78479-03-5

Molecular formula:

C14 H14 Cl2 O2

IUPAC Name:

(1R,3S)-3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropane-1-carboxylic acid

Test material form:

solid: crystalline

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: WINKELMANN, Borchen, Kreis Paderborn (Germany)
- Weight at study initiation: ca. 160-200 g
- Fasting period before study: 16 hours
- Housing: Makrolon cages Type III (5 animals per cage), Low-dust wood pellets were used as litter.
- Diet: "Altromin 1324 - dietary diet for rats and mice" (producer: Altromin GmbH)
- Water (e.g. ad libitum): tap water.
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2°C
- Humidity (%): 40 - 60 %
- Photoperiod (hrs dark / hrs light): 12 hours / 12 hours

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: water with 0.5 % of Tylose

Doses:

50 - 100 - 250 - 400 - 450 - 500 - 630 - 750 - 800 - 900 - 1000

No. of animals per sex per dose:

50 (5 males) - 100 (5 males and 5 females) - 250 (5 males and 5 females) - 400 (5 females) - 450 (5 females) - 500 (5 males and 5 females) - 630 (5 males) - 750 (5 females) - 800 (5 males) - 900 (10 males) - 1000 (5 males and 5 females)

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of weighing: just before test and then weekly
- Frequency of observations: the behavior and the appearance were determined several times on the application day / exposure day and thereafter twice per day.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 620 mL/kg bw

Based on:

test mat.

95% CL:

>= 500.1 - <= 770.7

Effect levels 2

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 935 mL/kg bw

Based on:

test mat.

95% CL:

>= 548.7 - <= 1 594

Clinical signs:

Loopy fur, apathy, diminished motility, wobbling gait with lateral and abdominal position, slackness, slowed and aggravated breathing.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The substance is Harmful if swallowed.