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Toxicological information

Genetic toxicity: in vivo

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genetic toxicity in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study does not meet the current guideline and was not performed under GLP.

Data source

Reference Type:

Materials and methods

Test material

Results and discussion

Applicant's summary and conclusion

Executive summary:

In examinations of the bone-marrow as well as germ cells of 2 strains of mice (ICR, CFLP) was found that NaSCN applied at a dose of 64 mg/kg daily on 3 consecutive days significantly decreases the frequency of the chromosome aberrations evoked by cyclophosphamide, from 68% to 52% in the bone-marrow cells ( α <1%) and from 25% to 16% in the germ cells (α < 5%). With regard to the medical and biological importance of the thiocyanates it seems promosing to subject these findings to a deeper treatment.