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EC number: 208-754-4
CAS number: 540-72-7
The key study for this endpoint is based on the well described literature study of Lanno and Dixon (1994) in which fathead minnows were exposed to potassium thiocyanate. The NOEC for decreased egg production, overt goitre, increased time to first spawn was 1.1 mg/L SCN-, equivalent to 1.84 mg/L KSCN
Four literature studies were available for
this endpoint, two for KSCN, and one for SCN- (with the identity of the
cation unknown). The study on the SCN- was considered unusable as only
the abstract was available. The remaining studies described toxicity of
potassium thiocyanate to fathead minnow (Pimephales promelas) and
rainbow trout (Oncorhynchus mykiss) and toxicity of sodium
thiocyanate to Cyprinus carpio. The key values from these studies
124 d NOEC = 1.1 mg/L SCN- (P. promelas) and
16 wk NOEC = 77 mg/L (O. mykiss). Both studies were well described and
with analytical monitoring of the SCN- concentrations. The study
describing chronic toxicity to P. promelas was chosen as the key study
for this endpoint due to the lower NOEC value of 1.1 mg/L SCN- (1.84
As there were no GLP studies for this
endpoint, further long term studies with fish were waived based on the
short term data for daphnia, fish and algae; where it was shown that
fish were the least sensitive organisms, thus it would not be expected
that they would be more sensitive in a long term study, thus conducting
a long term fish study would add no scientific value, except to use a
lower assessment factor. Also due to ethical reasons, it would be
inappropriate to conduct a long term fish study.
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