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EC number: 208-754-4
CAS number: 540-72-7
The key study for this endpoint is from the study of Bogers (1999) carried out at NOTOX BV, which was conducted according to OECD 203, under GLP and with analystical monitoring of test substance (ammonium thiocyanate). The LC50 was 65 mg/L. When expressed as SCN- content, the LC50 was 50 mg/L SCN-
Seven studies were reviewed for this
endpoint, of which two were conducted under GLP with analytical
monitoring, and the rest were literature studies, non GLP, with no
analytical monitoring. The key study chosen for this endpoint is from
the study of Bogers (1999) carried out under GLP, with LC50 value of 65
mg/L. Two studies with lower EC50 values were disregarded due to the
Study I: Tooby et al (1975):
The identity of the cation attached to
thiocyanate is not mentioned, and the test compound is only identified
as containing 15 % thiocyanate, with no further information on what
constitutes the remaining 85 %. Although a low LC50 value of 0.46 mg/L
was obtained, the effect could not be attributed solely to the
thiocyanate ion due to the lack of identity of the remaining 85%.
Study II: Bhunia et al (2000):
This study had a LC50 value of 13.4
mg/L for NH4SCN but was disregarded for the following reasons:
a. it uses a non standard and tropical
b. the size of the fish used for this
study (10 cm) is bigger than the standard range (2 - 6 cm)
c. there is no description of the
rearing conditions of the fish, thus study cannot be reproduced
d. there was no analytical measurement
of ammonium thiocyanate in the test
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