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EC number: 208-754-4
CAS number: 540-72-7
Thiocyanates are ubiquitous in living nature. Thiocyanates are not genotoxic, and there is no evidence from repeated dose studies that thiocyanate is able to induce hyperplasia and/or pre-neoplastic lesions.
Available information indicates that
thiocyanates are not genotoxic and do not lead to hyperplasia and/or
pre-neoplastic lesions, and thus do not need to be classified.
A chronic study (Lijinsky W, Kovatch
RM Toxicol Ind Health 1989 Jan 5:1 25-9) in rats supplied with 0.32%
thiocyanate together with sodium nitrite (0.2%) in their drinking water
for at least for 2 years, showed no effects in survival, or in the
incidence of any tumor that could be related to the treatment.
Thiocyanates are naturally occurring
substances with ubiquitous presence in living nature. Many studies
evaluated the background thiocyanate levels in serum of man showing
levels between 23 to 50 µmol/L to up to 100 µmol/L in case of smokers.
Thiocyanates are not genotoxic, and there is no evidence from repeated
dose studies that thiocyanate is able to induce hyperplasia and/or
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