Registration Dossier
Registration Dossier
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EC number: 221-657-1 | CAS number: 3179-47-3
Endpoint summary
Administrative data
Description of key information
Skin irritation
n-Decyl methacrylate was slightly irritating in a primary skin irritation study with in rabbits The substance is slightly irritating, but not irritating according to EU criteria. The result is confirmed by read across to Isodecyl methacrylate, 2-Ethylhexyl methacrylate (C8 ester) and Methacrylic ester 12,6.
Eye irritation
In a primary eye irritation study in rabbit, (OSHA Toxicity Screening Test, according to Draize) n-Decyl methacrylate showed no irritating properties.The result is confirmed by read across to Isodecyl methacrylate, 2-Ethylhexyl methacrylate (C8 ester) and Methacrylic ester 12,6.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
n-Decyl methacrylate was slightly irritating in a primary skin irritation study with in rabbits The substance is slightly irritating, but not irritating according to EU criteria. The result is confirmed by read across to Isodecyl methacrylate, 2-Ethylhexyl methacrylate (C8 ester) and Methacrylic ester 12,6.
Eye irritation
In a primary eye irritation study in rabbit, (OSHA Toxicity Screening Test, according to Draize) n-Decyl methacrylate showed no irritating properties.The result is confirmed by read across to Isodecyl methacrylate, 2-Ethylhexyl methacrylate (C8 ester) and Methacrylic ester 12,6.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available. Comparable to guideline study. Study well documented, meets generally accepted scientific principles, acceptable for assessment. The key study is not GLP compliant and has Klimisch score 2.
Justification for selection of eye irritation endpoint:
Only one study available. Comparable to guideline study. Study well documented, meets generally accepted scientific principles, acceptable for assessment. The key study is not GLP compliant and has Klimisch score 2.
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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