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EC number: 201-188-9
CAS number: 79-24-3
Table 1 Survival following two years exposure to Nitroethane
Male and female Long-Evans rats were exposed by inhalation to vapors of nitroethane (NE) at either 100 ppm or 200 ppm, seven hours per day, five days per week for two years. General observations were made daily and body weights were obtained weekly or biweekly.
During the study any rats that were found dead or sacrificed moribund were given a thorough gross examination and tissues retained for microscopic examination. After two years of inhalation of NE, all surviving rats were sacrificed. Blood samples were obtained from selected individuals for hematology and serum chemistry studies. All rats were examined histopathologically.
Exposure of the rats to NE had no pharmacologic effects nor were there any effects on mortality of rats of either sex at either level of exposure. Body weights of both sexes of both exposed groups were slightly less than controls, but lack of a well-defined dose-response relationship suggested the involvement of factors other than just exposure to NE. There were no effects of.exposure to NE on hematology. There were no biologically significant effects of exposure to NE on clinical chemistry or on organ weights. There was no significant difference in the non-neoplastic or neoplastic pathology related to exposure to NE.
A two year inhalation study in long-evans rats failed to show any gross or histopathological evidence for tumor formation. Therefore, nitroethane is not classifiable under GHS.
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