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EC number: 201-188-9
CAS number: 79-24-3
During the induction phase the guinea pigs in Group I showed some skin
reactions when injected with 10% (first two injections) and 5% (third
injection) solution, so the last seven injections were made with a 1%
solution of P-1355. None of the animals in Group III showed any skin
reactions. The animals in Group II showed mild to necrotic skin
reactions during the entire induction period. At challenge, Group I
(treatment group) and Group III (negative control) guinea pigs were
intradermally injected with 1.0% solution of P-1355, and none of the
animals in Group I showed any skin reactions, but two animals at 24 h
and one animal at 48 h in Group III showed mild reactions.
Table 1 P-1355 Intradermal Sensitization Challenge Skin Reactions Scores
in Guinea Pigs
Induction dose % conc.
10 to 1
Reaction scored at (h)
No. reacted/No. challenged
The dermal sensitization potential of nitroethane was examined using the
method of Landsteiner and Jacobs. Nitroethane (P-1355) was a
non-sensitiser to the guinea pigs under the conditions of this test. The
positive control DNCB gave an expected positive response.
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