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EC number: 201-188-9
CAS number: 79-24-3
This summary only describes procedures and results related to fertility. Repeated dose and developmental data are discussed in Sections 5.4 and 5.8.2, respectively. The authors considered the toxicological significance of reduced litter sizes at 96 ppm as equivocal, as there were no apparent effects on any other reproductive parameter examined, nor were there any corroborating findings revealed at gross or histopathological examination. The authors suggested that the slightly reduced litter size in animals exposed to 96 ppm 1-nitropropane was likely secondary to maternal toxicity and/or stress associated with nasal irritation. The authors also stated that the increases in mean pup weights at 96 ppm were most likely secondary to the smaller litter size in the 96 ppm group, as pup weight varies inversely with litter size.
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