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EC number: 201-188-9
CAS number: 79-24-3
Nitroethane was not irritating to the skin in the Draize test.
No additional information available.
The skin irritation potential of nitroethane was examined. Of the six rabbits tested, there was no irritation observed on intact skin. On abraded skin, only one had erythema and edema observed at the abraded application site at the end of the exposure period. None of the rabbits exhibited irritation 48 hours later. Thus using the criteria of OECD Guideline 404 of testing only intact skin, nitroethane (P-1355) produced no irritation in rabbits.
Table 1 Summary of Primary Eye Irritation Scores
According to the classification used, the two most severe readings would equate to moderately and mildly irritating. In the case of the rabbit with a score of 18, the cornea opacity and area was rated a 1 and 1, respectively. Iris was rated a 1. Conjunctival rednes, chemosis, and discharge were 2, 1 and 1, respectively. By 48 hours, the only positive symptoms in this rabbit was conjunctival redness and chemosis which were 2 and 1, respectively. Thus the observed effects were considered to be minimal even though the rating scheme would classify the effect as moderate.
The eye irritation potential was evaluated using the U.S. Federal Hazardous Substances Act Regulation (16 CFR Part 1500). Based on the results of this test, nitroethane is equivocal as a primary eye irritant. The maximum average eye irritation score was 6.2 at 24 hours after dose administration. Based on this score, nitroethane is considered mildly irritating to rabbit eyes.
The skin irritation potential of nitroethane was examined in three studies. In one study, the test material was slightly irritating to the skin in the Draize test. In the remaining studies, the material caused no irritation to intact skin but caused very slight redness and scab formation to abraded skin.
Three eye irritation studies have been conducted on nitroethane. In one study, slight pain was noted following application. In the three studies, very slight to slight eye irritation was observed which essentially subsided within 24 hours in two studies and minimal irritation in the third study.
Nitroethane was not irritating when applied to intact skin and therefore not classifiable under GHS
Nitroethane was only slightly irritating to the eyes and not classifiable under GHS.
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