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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline with acceptable restrictions (limited documentation)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979
Reference Type:
secondary source
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: According to Draize (FR 38, No. 187, §1500.42 p. 27019 (1973)
Deviations:
yes
Remarks:
only 3 animals tested
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Neodecanoyl chloride
EC Number:
254-875-0
EC Name:
Neodecanoyl chloride
Cas Number:
40292-82-8
Molecular formula:
C10H19ClO
IUPAC Name:
2,2-dimethyloctanoyl chloride
Details on test material:
Neodecanoyl chloride from BASF AG, substance No. 77/807. Degree of purity not reported.

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Gaukler (breeder)
- Mean weight at study initiation: 2.67 kg


ENVIRONMENTAL CONDITIONS
not reported

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
100 µL
Duration of treatment / exposure:
Treatment was once. The eye was left unwashed.
Observation period (in vivo):
72 h
Number of animals or in vitro replicates:
3
Details on study design:
APPLICATION
The TS was applied into the conjunctival sac of the rabbit's eye.

EXAMINATION
Eye reactions were examined 24, 48, and 72 hrs after application.

EVALUATION
Reactions of cornea, iris, and conjunctivae were scored according to the table of Draize.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
other: see table for details
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
2
Reversibility:
other: no effects
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0.67
Max. score:
3
Reversibility:
fully reversible within: 72 h
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects

Any other information on results incl. tables

Exposition:  24 h              
Animal  Reading  Opacity Cornea area Iritis Redness Chemosis Discharge Symptoms
1 24 h 0 0 0 1 0 0  
2 24 h 0 0 0 2 0 0  
3 24 h 0 0 0 2 0 0  
1 48 h 0 0 0 0 0 0  
2 48 h 0 0 0 1 0 0  
3 48 h 0 0 0 0 0 0  
1 72 h 0 0 0 0 0 0  
2 72 h 0 0 0 0 0 0  
3 72 h 0 0 0 0 0 0  
1 24 - 72 h 0.00   0.00 0.33 0.00    
2 24 - 72 h 0.00   0.00 1.00 0.00    
3 24 - 72 h 0.00   0.00 0.67 0.00    
mean  24 - 72 h 0.00   0.00 0.67 0.00    

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS