Neodecanoyl chloride

Endpoint summary

Description of key information

Neodecanoyl chlorde is of moderate oral toxicity  and is very toxic via inhalation.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

1 760 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

400 mg/m³ air

Additional information

Sprague-Dawley rats (5/sex/dose) were exposed to NdCl in olive oil via gavage at doses of 1000, 1470, 2150, and 3160 mg/kg-bw (BASF, 1979). The number of deaths was as follows: 1/10 at 1000 mg/kg, 3/10at 1470 mg/kg6/10 at 2150 and10/10 at 3160 mg/kg Animals that died during the study had distension of the GI tract with diarrheic gut contents. No changes were noted at necropsy in animals that survived. The LD₅₀value was 1760 mg/kg-bw in males and females.

 

In a guideline study (OECD TG 403), Wistar rats (5/sex/concentration) were exposed to NdCl as a vapor for four hours at analytical concentrations of 0, 0.12, 0.27, 0.41, and 0.62 mg/L and observed for 14 days (BASF, 1994). None of the animals exposed to 0.12 or 0.27 mg/L died. All 5 males and 2 females exposed to 0.41 mg/L died within 1 day. All animals exposed to 0.62 mg/L died during exposure. Accelerated and irregular respiration, grasping, snout wiping were noted. Gross pathology of animals that dies revealed hyperemia, oedema, and focal emphysema of the lungs. The 4-hr LC₅₀value for males and females was 0.4 mg/L.

Justification for classification or non-classification

According to the results presented above neodecanoyl chloride is classified as very toxic by inhalation (acute inhal. Cat 1 and R26) and harmful after swallowing ((acute oral cat 4; R22). No classification suggested for acute dermal toxicity as criteria of regulations 67/548/EC and 1272/2008/EC are not met, no data is available, respectively.