Neodecanoyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study. Restriction: degree of purity not reported

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Neodecanoyl chloride

EC Number:

254-875-0

EC Name:

Neodecanoyl chloride

Cas Number:

40292-82-8

Molecular formula:

C10H19ClO

IUPAC Name:

2,2-dimethyloctanoyl chloride

Details on test material:

Neodecanoyl chloride from BASF AG, substance No. 77/807. Degree of purity not reported.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

ANIMALS
Body weights: 200-220 g (m); 170-180 (f).
Fasting: overnight, 15 - 20 h before treatment.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

Dose volume: 10 ml/kg bw.
Concentration of TS: 10, 14.7, 21.5, and 31.6%

Doses:

1000, 1470, 2150, and 3160 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Observation period: 14 days.
Observations: signs of toxicity daily during the observation period. Animals were weighed 2 to 4, 7, and 13 days after treatment.
Examination: autopsy after sacrifice 14 days after treatment.

Statistics:

Company-owned software was used to calculate male and female LD50 values, confidence intervals, slope factor and homogeneity.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 760 mg/kg bw

95% CL:

1 429 - 2 163

Mortality:

All deaths occurred within 1 day of dosing. The number of
deaths in each group was:

Dose level males females
-----------------------------------------
1000 mg/kg 1/5 0/5
1470 mg/kg 1/5 2/5
2150 mg/kg 3/5 3/5
3160 mg/kg 5/5 5/5
-----------------------------------------

Clinical signs:

other: Signs of toxicity included lethargy, atony, abnormal agitation, abnormal positioning, convulsions, rough fur, dyspnea, and general poor condition at 1000 mg/kg bw. Additionally giddiness, reduced pain reflex, narcosis-like state, spastic gait at 1470 and

Gross pathology:

Animals that died during the study had distension of the GI tract with diarrheic gut contents. No changes were noted in animals that survived.