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EC number: 219-799-4
CAS number: 2536-05-2
Table 1: Summary of irritant effects on the skin (Exposure: 4 hours)
Observation time 1h 24h 48h 72h day7 day14
(after patch removal)
and eschar formation 0 0 0 1 1 0
Oedema formation 0 0 0 1 0 0
and eschar formation 0 2 2 2 1 0
Oedema formation 0 1 1 1 0 0
and eschar formation 0 1 2 3 1 0
Oedema formation 0 0 1 2 0 0
Animal 1, 2 and 3: desquamation on day 7 after patch removal
In a dermal irritation/corrosion study according to OECD TG 404 the test substance was applied under semiocclusive dressings for 4 hours to the shaved skin of 3 female rabbits. Skin irritation was assessed after 1, 24, 48, 72 hours and 7 days using the Draize scale. The mean irritation index for erythema was 1.4 of max. 4 (0.3-2.0), the mean irritation index for edema was 0.8 of max. 4 (0.3 -1.0). Signs were fully reversible in all animals within two weeks. The weight of these evidences indicates that the test substance may be considered as "slightly irritating to the skin". No relevant systemic intolerance reactions were observed.
Based on the test results, GHS criteria for classification are not met. However, 2,2’-MDI is harmonized classified in the European Union with H315 CLP Annex VI Regulation (EC) No 1272/2008 (CLP regulation).
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