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EC number: 219-799-4
CAS number: 2536-05-2
The results of the GastroPlus dermal absorption modeling show that 36 MDI constituents would have lower absorption into the skin and bioavailability than the three monomeric MDI isomers. MDI constituents with MW > 1000 are predicted to have the lowest bioavailability. These results are consistent regardless of vehicle solvent, test substance concentration, exposure time, or metabolic clearance rates within the skin compartments.
The results of these in silico evaluations should be useful in category-based, Read-Across Assessments for monomeric MDI isomers and modified MDI substances.
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