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EC number: 453-230-2
CAS number: 406679-89-8
During the induction phase the guinea pigs (10 test group, 5 control
group all females, strain: Hsd Poc: DH) were intradermally injected with
1% test item (diluted in Cotton Seed Oil) and topically treated with
100% test item. After a latency of 2 weeks - to allow a potential
reaction of the immune system - the animals were challenged with 100%
test item on the flank. The grade of skin reactions was compared to
control animals, which were treated with Cotton Seed Oil during the
induction stage, and during challenge phase with 100% test item,
The sensitization rate after application of the test item was 70 %.
Under the test conditions described below the test item showed clear
sensitizing properties. According to the EC criteria for classification
and labelling requirements for dangerous substances and preparations
(Guidelines in Commission Directive
93/21 EEC) labelling is necessary as the sensitization rate was more
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