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EC number: 453-230-2
CAS number: 406679-89-8
Two groups (groups A and B) of 5 male and 5 female rats were exposed
during a single period of four hours to a test atmosphere
containing the test material at the limit concentrations of 2.04 and
0.52 g/m3, respectively. To explore the toxicity below the limit
concentration of 0.5 g/m3, a third exposure at 0.26 g/m3 was performed
with five pairs of animals exposed during 4 hours, 2 hours, lhour, 30
minutes and 15 minutes, respectively.
The salient effects of the study were the 100% mortality in groups A and
B. In contrast the animals of group C all survived. Treatment-related
effects observed during exposure consisted of breathing abnormalities
that were related to concentration and duration. Shortly after exposure
especially for the animals of group B an extensive list of clinical
signs was noted. In the animals of group C exposed during 2 or 4 hours
breathing abnormalities were seen on day 1 and day 2, but not
thereafter. Effects on body weight gain during the fust week were
apparant in the animals of group C exposed during 4 hours, but not in
the other animals of that group. Also, treatment related macroscopic
findings were not found in the animals of group C, although red or dark
red discoloured or haemorrhagic lungs
were found in the animals of groups A and B that were found dead in the
first few days after exposure.
Because mortality was 100% in animals exposed to concentrations of 2.04
or 0.52 g/m3, the 4-hour LC50 of inhalatory exposure to vapour of the
test material was lower than 0.52 g/m3. Additional exploration at 0.26
g/m3, using exposure durations ranging from 4 hours to 15 minutes,
suggested that the 4-hour LC50 was higher than 0.26 g/m3, hence between
0.26 and 0.52 g/m3.
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