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EC number: 453-230-2
CAS number: 406679-89-8
An acute eye Irritation/Corrosion test according to OECD 405 was
performed. The test item was applied to the lower conjunctival sac of
one eye of 3 female New Zealand White Rabbits HsdIf:NZW at a dose of 0.1
ml per application site. The untreated eye served as control. The test
item produced corrosion and irreversible effects in all animals tested. No
corneal lesions were found upon fluorescein examination at the final reading.
No other toxic effects were observed. Throughout the observation period
no weight loss was recorded .
The mean scores of the 24, 48 and 72 hour readings exceeded the limit
values according to Directive 93/21 EEC in any case. Therefore, the
substance has to be classified and has obligatory labelling requirement
for eye irritation.
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