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EC number: 453-230-2
CAS number: 406679-89-8
An acute toxicity test according the acute toxic class method (OECD 423)
was performed. In the first step the test item was given at a dose of
200 mg/kg bw to a group of 3 male rats (HsdBrlHan:WIST) in a single
exposure via oral gavage. In the second step the test item was given at
the same dose to a group of 3 female rats (HsdBrlHan:WIST) in a single
exposure via oral gavage. The dosage of 200 mg/kg bw caused no
compound-related mortality neither in the three male nor in the three
female animals within 14 days p. appl.. According to the acute toxic
class method regime, in a third step the test item was given to a
further group of three male animals in a dose of 2000 mg/kg bw. Any of
the animals of step 3 showed reduced spontaneous activity, prone
position, apathy and respiratory distress. The dosage of 2000 mg/kg bw
caused compound-related mortality in animal
No. 1 within 5 hours and in animals No. 2 and 3 within 3 hours p. appl..
According to the acute toxic class method regime, no further testing was
required. According to the results obtained the LD50 was determined to
be between 300 and 500 mg/kg bw.
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