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EC number: 453-230-2
CAS number: 406679-89-8
An acute dermal Irritation/Corrosion test according to OECD 404 was
performed. The test item was semi-occlusively applied to the skin on 3
female New Zealand White Rabbits HsdIf:NZW and held in contact
throughout a 4 hour period. The test item showed slight irritant effects
on the intact skin after a contact time of 4 hours. All animals showed
erythema grade 1 at the 1 h, 24 h, 48 h, 72 h, 96 h, 120 h as well as
144 hours readings after removal of the dressing. No signs of irritation
were recorded for any animals at the 168 hours readings. No other
clinical signs of toxicity were found. There were no significant body
weight changes during the contact and observation period. Therefore, the
test item does not have to be classified and has no obligatory labelling
requirement for skin irritation.
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