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EC number: 947-946-9
CAS number: -
test item was tested to evaluate its mutagenic potential by measuring
its ability to induce reverse mutations at selected loci of several
strains of Salmonella typhimurium and at the tryptophan locus of
Escherichia coli strain WP2 uvrA in the presence and absence of an
exogenous metabolic activation system. Ethanol
was used as the vehicle.
the preliminary toxicity assay, the dose levels tested were 6.67, 10.0,
33.3, 66.7, 100, 333, 667, 1000, 3333 and 5000 µg per plate. Precipitate
was observed beginning at 3333 or at 5000 µg per plate with all
was observed beginning at 3333 µg per plate with tester strain WP2 uvrA
in the absence of S9 activation. Based
upon these results, the maximum dose tested in the mutagenicity assay
was 5000 µg per plate.
the mutagenicity assay, the dose levels tested were 50.0, 150, 500, 1500
and 5000 µg per plate. No
toxicity was observed. Precipitate
was observed beginning at 1500 µg per plate with all conditions. No
positive mutagenic responses were observed with any of the tester
strains in either the presence or absence of S9 activation.
results indicate the test item was negative for the ability to induce
reverse mutations at selected loci of several strains of Salmonella
typhimurium and at the tryptophan locus of Escherichia coli strain WP2
uvrA in the presence and absence of an exogenous metabolic activation
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