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EC number: 947-946-9
CAS number: -
Conclusion on P / vP properties:
vP (and P)
The test item is not readily biodegradable
(11% degradation in 28 days) andis
therefore considered to be very Persistant (vP) based upon the
Conclusion on B / vB properties:
an unknown or variable composition, complex reaction products and
biological materials (UVCB substance) containing molybdenum and is
essentially insoluble in water. QSAR calculations provide water
solubility values below10-6mg/L. The partition coefficient
(Log Pow)of the substance was estimated to be18.94
using EPI SuiteTMsoftware. The UVCB substance includes a
fraction that does not contain molybdenum. The water solubility and Log
fraction without molybdenumare5
x 10-5mg/mL at 20 °C and 5.84, respectively. The typical
molecular mass of the substance (C32H68Mo2P2O6S6)
is 995.11 Daltons. These data indicate that the substance is relatively
large (> 500 Daltons), has very low water solubility (< 0.1 mg/L), and
is a highly lipophilic (Log Pow > 5.6) molecule, and thus the substance
is not bioavailable via the oral route in accordance with Lipinski's
rule of five, and thus is not expected to be absorbed by fish. In
addition, acute oral toxicity study in rats did not show any systemic
effects up to 2000 mg/kg, the highest doses tested. Although
the substance was not tolerated at 10 and 21.5 ml/kg in acute oral
toxicity study in rats with oral LD50of 6.81 ml/kg body
weight, equivalent to 7709 mg/kg (relative density of 1.132), the
observations were largely local gastrointestinal effects due to overload
of highly hydrophobic substance in gastrointestinal tract, diarrhea with
the test substance in stools, and corresponding poor clinical
conditions. Lower thymus weight and higher liver
weight were noted at 1000 mg/kg/day, the highest dose tested, in a 6-day
repeated dose oral range-finding toxicity study in rats. Systemic
effects were also notedin the combined repeated dose oral
toxicity study with the reproductive/developmental toxicity screening
test in rats, which are hepatocellular
hypertrophy, thyroid follicular cell hypertrophy and mucosal hyperplasia
with erosion or ulceration in the nonglandular stomach. The thyroid
follicular cell hypertrophy was likely secondary to the liver effect and
the mucosal hyperplasia may be secondary to direct irritation of the
mucosa. However, no information is currently available on possible
degradation products produced in the gastrointestinal tract.
Conclusion on T properties:
No evidence of toxicity has been reported in
any study on the test item.
The primary route of test item release release will be to wastewater.
It may be released to air through use processes, however, the vapour
pressure is 0.0045 Pa at 25°C
and therefore air exposure is expected to be negligible.
Release to soil may occur from spreading of STP sludge’s, however this
is advised against.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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