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EC number: 221-336-6
CAS number: 3069-29-2
key skin sensitisation study, conducted according to OECD Test Guideline
406 and in compliance with GLP, concluded the registered substance,
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine (CAS No. 3069-29-2, EC
No. 221-336-6), to be a skin sensitiser (Safepharm Laboratories Ltd,
1988). 19/20 test animals showed positive responses at both 24 and
The key skin sensitisation study is the only available
study for this endpoint. The study was conducted according to OECD Test
Guideline 406 and in compliance with GLP.
Twenty test and ten control animals were used for the
main study. Following sighting studies, the following concentrations
were used in the induction and challenge phases:
Intradermal Induction: 0.1% (w/w) in distilled water
Topical Induction: undiluted as supplied
Topical Challenge: undiluted as supplied
The test material produced a 95 % (19/20) sensitisation
rate and was concluded to be sensitising to guinea pig skin.
A supporting skin sensitisation test for the analogue
(CAS No. 1760-24-3, EC No. 217-164-6)
included only to support the read-across justification for the genetic
toxicity endpoint currently using this analogue substance.
Based on the available information,
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine is classified for skin
sensitisation Category 1A, H317: "May cause an allergic skin reaction"
according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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