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Physical & Chemical properties

Water solubility

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water solubility
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)

Description of key information

Water solubility [N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine]: 8.6E+05 mg/L (QSAR)

Water solubility [N-[3-(dihydroxymethylsilyl)propyl]ethylenediamine]: Above approximately 1000 mg/L condensation reactions can occur over time, limiting the concentration dissolved in water. The calculated water solubility is 1.0E+06 mg/L (QSAR)

Water Solubility [methanol]: miscible at 20°C

Key value for chemical safety assessment

Water solubility:
860 000 mg/L
at the temperature of:
20 °C

Additional information

The requirement to conduct a water solubility study for the submission substance is waived on the basis that it hydrolyses very rapidly to form N-[3-(dihydroxymethylsilyl)propyl]ethylenediamine and methanol.

However, the water solubility of N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine has been calculated using a validated QSAR method to be 8.6E+05 mg/L.

The hydrolysis product, N-[3-(dihydroxymethylsilyl)propyl]ethylenediamine may undergo condensation reactions in water; this becomes important above approximately 1000 mg/L and can limit the concentration dissolved in water. For details, see the overall physicochemical properties discussion.

N-[3-(Dihydroxymethylsilyl)propyl]ethylenediamine is very hydrophilic and hence the calculated solubility is 1E+06 mg/L at 20°C using a QSAR method. However, the saturation concentration of N-[3-(dihydroxymethylsilyl)propyl]ethylenediamine in water is limited by condensation reactions rather than lack of true solubility, as discussed above. A prediction of 1E+06 mg/L is indicative but has no practical meaning. The prediction is however considered valid for environmental exposure modelling because it is considered to adequately describe the hydrophilicity of the substance and hence the partitioning behaviour.


Methanol is reported to be miscible in water at 20°C (OECD 2004).


OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1

PFA (2016am). Peter Fisk Associates, Silanols and aquatic systems, 404.105.003