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EC number: 221-336-6
CAS number: 3069-29-2
No terrestrial plant
toxicity data are available with N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine
An OECD TG 208 study is
proposed with the registration substance.
The registration substance
falls within soil hazard category 3 as defined in REACH R.7 (ECHA 2017);
high persistence (DT50 >180 days) but there is no indication
that the substance is very toxic to aquatic organisms (E(L)C50
In this situation, a
screening approach is applied: a confirmatory long-term terrestrial test
in addition to the equilibrium partitioning approach with an extra
factor of ten.
The PEC × 10 / PNECscreen
based on the equilibrium partitioning method indicates the substance
will have a risk characterisation ratio (RCR) >1. The
highest terrestrial RCR based on PEC x 10 / PNEC is 4.69 related to
deposition from air.
ECHA guidance Chapter R.7c,
Table R.7.11—2 states the following (ECHA 2017): If PEC/PNECscreen >1 or
indication of risk from confirmatory long-term soil toxicity test:
Conduct long-term toxicity tests according to the standard information
requirements Annex X (invertebrates and plants), choose lowest value for
derivation of PNECsoil.
A long-term toxicity to
terrestrial plants test in accordance with test guideline OECD 208 is
tiered testing approach is proposed with the OECD 222 test to be
conducted first in order to
establish that stability and homogeneity is feasible for the earthworm test
prior to conducting the OECD 208 plant test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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