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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to soil microorganisms

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Administrative data

Link to relevant study record(s)

toxicity to soil microorganisms
Type of information:
experimental study planned
Study period:
After approval by ECHA
according to guideline
OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
Principles of method if other than guideline:
The study is to be conducted with the hydrolysis product of the registered substance, in view of its hydrolysis rate - see IUCLID Section 6.3, CSR Section 7.2, for further details of the risk assessment approach.

Description of key information

Key value for chemical safety assessment

Additional information

No soil microorganisms toxicity data are available with N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine (CAS 3069-29-2).

An OECD TG 216 study is proposed with the registration substance.

Toxicity was observed in the aquatic microorganism test (IUCLID Section 6.1.7, CSR Section 7.4), read across from a structural analogue (16 hour EC50 67 mg/L; EC10 25 mg/L (Pseudomonas putida, growth rate) (Diefenbach, 1994)). ECHA guidance Chapter R.7c (ECHA 2017) states “Where inhibition of sewage sludge microbial activity has been observed in Annex VIII testing, a test on soil microbial activity will additionally be necessary for a valid PNEC to be derived.” A soil microorganisms nitrogen inhibition test (OECD 216) is therefore proposed.