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EC number: 221-336-6
CAS number: 3069-29-2
A group of three fasted rats received a single oral gavage dose of the
test substance, formulated in 1% w/v aqueous methylcellulose, at a dose
level of 2000 mg/kg bodyweight. As a result of mortalities at this
dosage indicating the acute lethal oral dose of the test material to be
less than 2000 mg/kg bw, in compliance with the study guidelines a
further group of three fasted females was dosed at 200 mg/kg. A group of
three fasted males was then dosed at 200 mg/kg to confirm results at
this dosage and complete the study.
All females dosed at 2000 mg/kg died within ca. 2 hours of dosing.
Macroscopic examination of decedents revealed a generalised congestion
in the majority of organs and tissues. Clinical signs of reaction to
treatment included piloerection, seen in all rats at both dosages. In
addition, hunched posture, waddling/unsteady gait, lethargy, abnormal
respiration, partially closed eyelids, pallid extremities, abnormal
faeces, ungroomed appearance, prostration, blue/cold extremities and
dark colouring to eyes were seen in one or more animals during the
study. Recovery of surviving rats at 200 mg/kg dose, as judged by
external behaviour, was complete by day 7. All surviving animals were
considered to have achieved satisfactory bodyweight gains throughout the
study. No macroscopic abnormalities were recorded for the animals killed
and examined at study termination on day 15.
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