Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 907-640-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older study widely cited for acute toxicity endpoints on many chemicals. Methods suffiently desribed to be considered reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity studies: List VI
- Author:
- Smyth H.F., et al.,
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal 23:95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Body weight: 2.5-3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- Unspecified
- No. of animals per sex per dose:
- 4 males per group
- Control animals:
- no
- Details on study design:
- Animals were immobilised for the 24 hour exposure. Mortality was followed for 14 day follow up period.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 mL/kg bw
- 95% CL:
- 6.8 - 14.8
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The LD50 was estimated to be 10 mL/kg, which is non-hazardous according to the EU and GHS criteria. As DPM has greater skin penetration rate compared with the tripropylene glycol monomethyl ether, this result is expected to adequately represent the acute dermal toxicity hazard of the reaction mass substance submitted for REACH registration.
- Executive summary:
Dipropylene glycol monomethyl ether (DPM) was tested for acute dermal toxicity in the male rabbit with a 24-hour occlusive dermal exposure followed by a 14-day follow up period. The LD50 was estimated to be 10 mL/kg (9510 mg/kg).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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