Registration Dossier
Registration Dossier
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EC number: 907-640-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The reaction mass containing DPM, TPM, and sodium methylate was shown in vitro to be corrosive to skin, and is presumed to be corrosive to the eyes. This result is supported by the pH range of the material (ph = 12 - 13.5), and the presence of a corrosive component at greater than 10% in the mixture.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation/corrosion
In an in vitro corrosivity test using reconstituted human epidermis, the test material was classified as corrosive to skin based on the reduction in viablity of reconstituted human epidermal tissue.
Eye irritation/corrosion
Based on the positive findings for corrosivity to skin in the in vitro skin assay, the test material was not tested for eye irritation/corrosion. This is in accord with REACH, annex VII, column 2 requirements.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
The reaction mass of dipropylene glycol monomethyl ether (DPM), tripropylene glycol monomethyl ether (TPM), and sodium or potassium methanolate catalyst, is corrosive to the skin and eyes due to the presence of the methanolate moiety at greater than 10%.
Under the EU DSD criteria, it would be rated C; R34 (Causes burns) and R41 (Risk of serious damage to eyes). Under the EU CLP criteria (EU Regulation 1272/2008), it would be rated Skin Corrosive, Category 1B and Eye Damage, Category 1.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
