Registration Dossier
Registration Dossier
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EC number: 801-072-3 | CAS number: 1052075-57-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A bioconcentration study with X-22-1622 was performed in common carp (Cyprinus carpio) based on a method similar to OECD Guideline 305 (i.e. Method for Testing the Degree of Accumulation of Chemical Substances in Fish Body) and according to GLP principles. Based on the measured residue levels in fish (<500 µg/kg wwt), and on the mean measured concentration in water (11.0 and 0.842 µg/L), the BCF values are <45 and <594 L/kg for exposure levels of nominal concentration in water of 10 and 1 µg/L, respectively.The BCF values are classified as reliable with restrictions since validation was only performed on two samples of water and fish (SANCO/3020/99 rev4 of 11/07/00 requires n=5 at LOQ and 10xLOQ).
Key value for chemical safety assessment
Additional information
A bioconcentration study with X-22-1622 was performed in common carp (Cyprinus carpio) based on a method similar to OECD Guideline 305 (i.e. Method for Testing the Degree of Accumulation of Chemical Substances in Fish Body) and according to GLP principles. In the uptake phase fish were exposed to two test concentrations, 1 µg/L (Level 2) and 10 µg/L (Level 1), during 28 days (flow-through system). The water concentration of the test item was maintained within ± 20% of the mean of the measured values during the uptake phase, mean measured concentrations were11.0 and 0.842 µg/L at nominal exposure levels of 10 and 1 µg/L, respectively. The test item was not detected in test fish samples at any sampling time (<500 µg/kg wwt, validated LOQ in fish).
A depuration phase was not performed as no significant uptake of the test item was recorded during the uptake phase.Based on the measured residue levels in fish (<500 µg/kg wwt), and on the mean measured concentration in water (11.0 and 0.842 µg/L), the BCF values are <45 and <594 L/kg for exposure levels of nominal concentration in water of 10 and 1 µg/L, respectively.The BCF values are classified as reliable with restrictions sincevalidation was only performed on two samples of water and fish (SANCO/3020/99 rev4 of 11/07/00 requires n=5 at LOQ and 10xLOQ).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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