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EC number: 801-072-3 | CAS number: 1052075-57-6
Dosing formulations were confirmed to be stable under the storage conditions, since the concentration of the test chemical in the formulations after storage were within 100 +/-10% of those analysed immediately after preparation (99.4% for 10.0 w/v% and 100% for 0.100 w/v%). The concentration of the test chemical in the 10.0, 3.00 and 1.00 w/v% formulations were within 100 +/-10% of each nominal concentration (99.3% for the 10.0 w/v%, 98.7% for the 3.00 w/v% and 96.6% for the 1.00 w/v% formulation.
Rats were exposed to 0, 100, 300 or 1000 mg/kg bw/d X-22-1622 in corn oil by gavage for 28 days according to OECD 407 and GLP. For the control group and the 1000 mg/kg bw/d group a recovery period of 14 days was included.
No (toxicologically relevant) effects were observed on mortality, clinical signs, functional behaviour, body weight, food consumption, haematology and urinalysis. Absolute and relative liver weight were increased in females at 1000 mg/kg bw/d, and accompanied by very slight or slight fatty changes of periportal hepatocytes in 4/5 females and slight or moderate microgranuloma in the liver in 3/5 females. Microgranuloma was also seen in one male at 1000 mg/kg bw/d. At 300 mg/kg bw/d very slight fatty changes of periportal hepatocytes were seen in 2/5 females and slight microgranuloma in 1/5 female. Liver effects had disappeared after recovery.
Based on the above results, the NOAEL was determined to be 100 mg/kg bw/d.
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