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EC number: 940-728-4 | CAS number: -
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MRD-83-207 was tested for acute oral toxicity in Sprague-Dawley rats in a limit dose assay. The test substance, a liquid, was administered as supplied. Animals were fasted overnight prior to treatment. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage (via a syringe) in a single oral dose. Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period. No deaths occurred during the study. Body weight gain was not affected by treatment. A/G staining was noted in all animals within the 6-hour observation period. In-life observations also included alopecia and unkempt coat. At necropsy, macroscopic examination of main organs showed lung discoloration in seven animals. As the acute oral LD50 was found to be greater than 5000 mg/kg b.w. under the conditions of the test, MRD-83-207 is not classified according to the criteria of Annex VI to Directive 67/548/EEC and CLP Regulation 1272/2008.
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